Concepcion (4-4) scattered two hits and walked a pair in a dominant performance.
Justin Interisano provided the game's only run with an RBI single that scored Josh Garton in the seventh. Angel Villalona added two singles and a double.
Justin Gideon and Andrew Mercier had Burlington's hits – both singles.
Rich Corrente (0-6) took the loss, giving up a run on eight hits with four strikeouts over eight innings.
Guelph improved to 14-19 with its fifth straight victory, and Burlington fell to 12-23.