| Num | Date | Teams | Newspaper Boxscore | Extended Boxscore |
|---|---|---|---|---|
| 1 | 2021-05-23 17:40:00 | Shakes 3 @ Holly Springs 6 |
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| 2 | 2021-05-25 07:09:00 | FT 6 @ Asheboro 6 |
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| 3 | 2021-05-25 12:00:00 | Shakes 5 @ Holly Springs 10 |
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| 4 | 2021-05-26 19:05:00 | Stars 0 @ Lexington Count 7 |
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| 5 | 2021-05-27 19:00:00 | Stars 3 @ Martinsville 12 | unavailable | |
| 6 | 2021-05-27 19:00:00 | Fungo 3 @ Wilson 8 |
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| 7 | 2021-05-28 19:56:18 | Locos 0 @ Wilson 0 |
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| 8 | 2021-05-28 20:05:00 | Stars 5 @ HP-Thomasville 3 |
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| 9 | 2021-05-29 18:00:00 | Disco Turkeys 6 @ HP-Thomasville 4 |
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| 10 | 2021-05-30 17:00:00 | Stars 0 @ HP-Thomasville 8 |
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| 11 | 2021-05-30 18:30:00 | FT 2 @ Wilson 7 |
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| 12 | 2021-05-31 19:00:00 | Disco Turkeys 3 @ Martinsville 12 | unavailable | |
| 13 | 2021-05-31 19:00:00 | Locos 8 @ Forest City 8 | unavailable | |
| 14 | 2021-05-31 19:08:10 | Stars 0 @ Asheboro 3 |
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| 15 | 2021-06-02 19:00:00 | Stars 1 @ Martinsville 9 |
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| 16 | 2021-06-02 19:00:00 | Disco Turkeys 2 @ HP-Thomasville 10 |
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| 17 | 2021-06-04 19:05:00 | Outlaws 7 @ Spartanburg 8 |
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| 18 | 2021-06-05 19:05:00 | Stars 0 @ Forest City 0 | unavailable | |
| 19 | 2021-06-06 17:45:00 | Tigers 11 @ Tri-City 6 |
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| 20 | 2021-06-09 19:00:00 | Owls 3 @ HP-Thomasville 13 |
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| 21 | 2021-06-09 19:00:00 | Owls 0 @ Martinsville 12 |
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| 22 | 2021-06-10 19:00:00 | Eggs 3 @ Florence 5 |
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| 23 | 2021-06-10 19:05:00 | 8's 0 @ Wilmington 6 |
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| 24 | 2021-06-11 19:00:00 | Spartanburg 3 @ Outlaws 2 |
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| 25 | 2021-06-11 19:05:00 | Breeze 5 @ Wilmington 1 |
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| 26 | 2021-06-11 19:05:00 | Stars 6 @ Lexington Count 13 |
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| 27 | 2021-06-12 18:00:00 | Disco Turkeys 2 @ HP-Thomasville 12 |
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| 28 | 2021-06-12 19:00:00 | Patriots 1 @ Tri-City 16 |
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| 29 | 2021-06-13 18:00:00 | Steamers 5 @ Wilson 6 |
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| 30 | 2021-06-14 19:05:00 | Twins 3 @ Morehead City 12 |
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| 31 | 2021-06-16 19:00:00 | Shakes 0 @ Holly Springs 3 |
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| 32 | 2021-06-17 19:05:00 | Pirates 8 @ Spartanburg 0 |
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| 33 | 2021-06-18 19:00:00 | Spartanburg 8 @ Outlaws 1 |
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| 34 | 2021-06-18 19:05:00 | Ironbirds 4 @ Wilmington 7 |
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| 35 | 2021-06-18 19:05:00 | Pirates 4 @ Lexington Count 2 |
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| 36 | 2021-06-19 18:30:00 | Shakes 1 @ Holly Springs 14 |
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| 37 | 2021-06-19 19:05:00 | Pirates 4 @ Spartanburg 0 |
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| 38 | 2021-06-19 19:05:00 | Sand Gnats 2 @ Wilmington 12 |
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| 39 | 2021-06-20 17:05:00 | Tides 1 @ Wilmington 6 |
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| 40 | 2021-06-20 17:40:00 | Shakes 3 @ Holly Springs 7 |
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| 41 | 2021-06-23 19:05:00 | Steamers 3 @ Morehead City 1 |
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| 42 | 2021-06-25 18:51:00 | River Bandits 4 @ Wilson 10 |
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| 43 | 2021-06-25 19:05:00 | Spartanburg 4 @ Outlaws 3 |
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| 44 | 2021-06-25 19:05:00 | Naturals 3 @ Wilmington 5 |
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| 45 | 2021-06-25 19:05:00 | Pirates 16 @ Lexington Count 8 |
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| 46 | 2021-06-26 19:00:00 | Sluggers 6 @ Tri-City 8 |
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| 47 | 2021-06-26 19:05:00 | Outlaws 5 @ Spartanburg 9 |
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| 48 | 2021-06-29 19:02:00 | Peninsula 0 @ Steamers 0 | unavailable | |
| 49 | 2021-06-30 19:00:00 | Monarchs 7 @ HP-Thomasville 10 |
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| 50 | 2021-07-01 19:00:00 | Locos 3 @ Martinsville 5 | unavailable | |
| 51 | 2021-07-02 19:05:00 | Stars 2 @ Forest City 5 |
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| 52 | 2021-07-02 19:05:00 | River Bandits 5 @ Wilmington 10 |
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| 53 | 2021-07-03 19:00:00 | Stars 2 @ Savannah 3 |
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| 54 | 2021-07-03 19:05:00 | Outlaws 1 @ Spartanburg 2 |
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| 55 | 2021-07-03 19:05:00 | Steamers 6 @ Wilmington 11 |
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| 56 | 2021-07-04 17:10:00 | Shakes 1 @ Holly Springs 2 |
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| 57 | 2021-07-04 19:00:00 | Spartanburg 4 @ Outlaws 10 |
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| 58 | 2021-07-07 19:00:00 | Owls 3 @ HP-Thomasville 2 |
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| 59 | 2021-07-08 19:00:00 | Stars 2 @ Spartanburg 9 |
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| 60 | 2021-07-09 19:00:00 | Outlaws 4 @ Spartanburg 5 |
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| 61 | 2021-07-09 19:00:00 | Knights 0 @ Wilmington 5 |
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| 62 | 2021-07-09 19:00:00 | Steamers 7 @ Peninsula 1 |
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| 63 | 2021-07-10 19:00:00 | Spartanburg 11 @ Outlaws 5 |
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| 64 | 2021-07-11 17:00:00 | Big Foots 3 @ HP-Thomasville 7 |
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| 65 | 2021-07-11 17:40:00 | Shakes 2 @ Holly Springs 8 |
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| 66 | 2021-07-11 18:07:00 | Pirates 0 @ Wilson 8 |
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| 67 | 2021-07-12 19:00:00 | Disco Turkeys 1 @ Martinsville 7 |
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| 68 | 2021-07-13 18:27:00 | Stars 7 @ Wilson 8 |
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| 69 | 2021-07-14 19:00:00 | Knights 0 @ Peninsula 15 |
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| 70 | 2021-07-14 19:05:00 | Nine 2 @ Morehead City 17 | unavailable | |
| 71 | 2021-07-15 19:05:00 | Fungo 2 @ Wilmington 0 |
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| 72 | 2021-07-15 19:05:00 | Stars 12 @ Lexington Count 11 |
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| 73 | 2021-07-16 19:00:00 | Spartanburg 10 @ Outlaws 7 |
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| 74 | 2021-07-17 19:00:00 | River Bandits 6 @ Peninsula 7 |
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| 75 | 2021-07-17 19:05:00 | Stars 5 @ Lexington Count 1 |
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| 76 | 2021-07-17 19:05:00 | Steamers 2 @ Wilmington 15 |
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| 77 | 2021-07-18 17:00:00 | Disco Turkeys 0 @ HP-Thomasville 13 |
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| 78 | 2021-07-21 19:00:00 | Stars 2 @ Asheboro 11 |
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| 79 | 2021-07-22 19:00:00 | Stars 8 @ Spartanburg 10 |
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| 80 | 2021-07-23 19:00:00 | Spartanburg 3 @ Outlaws 5 |
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| 81 | 2021-07-23 19:05:00 | Fungo 4 @ Wilmington 0 |
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| 82 | 2021-07-24 19:00:00 | Eggs 7 @ Florence 4 |
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| 83 | 2021-07-26 19:00:00 | Big Foots 6 @ Martinsville 4 |
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| 84 | 2021-07-27 19:05:00 | Shakes 7 @ Holly Springs 6 |
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| 85 | 2021-07-29 19:00:00 | Outlaws 2 @ Spartanburg 3 |
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| 86 | 2021-07-31 17:00:00 | Outlaws 2 @ Spartanburg 10 |
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| 87 | 2021-08-01 17:40:00 | Shakes 2 @ Holly Springs 7 |
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| 88 | 2021-08-01 17:45:00 | Bon Air 10 @ Tri-City 9 |
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